Suppression by LH-releasing hormone (LHRH) of the augmenting effect of estradiol on the secretion of LH and FSH by the rat pituitary gland |
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| Authors: | G. A. Schuiling N. Pols-Valkhof T. R. Koiter |
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| Affiliation: | (1) Division of Reproductive Biology, Department of Obstetrics and Gynaecology, University of Groningen, 59 Oostersingel, NL-9713 EZ Groningen, The Netherlands |
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| Abstract: | Summary Estradiol sensitizes the pituitary gland for the gonadotropin-releasing activity of LHRH. LHRH desensitizes the pituitary gland and does so in a dose-dependent manner. Moreover, LHRH dose-dependently suppresses the sensitizing effect of EB. In rats with an LHRH concentration in the plasma of about 90 pg/ml, the sensitizing effect of estradiol is absent. |
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| Keywords: | LHRH estradiol LH/FSH secretion |
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