Local adjuvants: The influence of sodium dodecylbenzene sulphonate on immunization with aerosolized antigen |
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| Authors: | R J F Markham B N Wilkie |
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| Institution: | (1) Department of Veterinary Microbiology and Immunology, University of Guelph, Guelph, Ontario, Canada |
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| Abstract: | Summary Guinea-pig respiratory and serum antibody responses were enhanced following exposure to aerosols of bovine IgG2 dissolved in solutions of sodium dodecylbenzene sulphate (SDBS). Enhanced response was seen in both primary and secondary immunization. Cell-mediated immune response (indirect macrophage migration influencing test) was not altered by SDBS. Results are discussed with a view to the possible utility of SDBS as adjuvant for prophylactic immunization.Acknowledgment. This research was supported by a grant from the Ontario Ministry of Health. The technical assistance of Ms Judy Little is gratefully acknowledged. |
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