| N-(4-对氟苯基-4-芳胺基)-丁基-N′-二苯甲基哌嗪及其衍生物的合成 |
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| 引用本文： | 宋艳玲,许家喜,胡京诞,金声.N-(4-对氟苯基-4-芳胺基)-丁基-N′-二苯甲基哌嗪及其衍生物的合成[J].北京大学学报(自然科学版),1991(6). |
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| 作者姓名： | 宋艳玲 许家喜 胡京诞 金声 |
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| 作者单位： | 化学系
(宋艳玲，许家喜，胡京诞)，化学系(金声) |
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| 摘 要： | 本文合成了N-对氟苯甲酰丙基-N′-二苯甲基哌嗪,并用它和芳香胺进行还原胺化反应,制备了一组标题化合物及其盐酸盐,目的是为了修饰心血管药物N-对氟苯甲酰丙基-N′-二苯甲基哌嗪的结构。这些化合物均为未见报导的新化合物,其结构得到了IR,~1H-NMR及MS等光谱证实。同时发现,在还原胺化反应中,亲核试剂芳胺的取代基对反应速度有明显的影响。
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| 关 键 词： | 哌嗪 西佛碱 分子筛 还原胺化反应 |
Synthesis of N-(4-p-fluorophenyl-4-arylamino)-butyl-N'-diphenylmethyl Piperazine and Its Derivates |
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| SONG Yanling,Xu Jiaxi,HU Jingdan,JIN Sheng.Synthesis of N-(4-p-fluorophenyl-4-arylamino)-butyl-N''''-diphenylmethyl Piperazine and Its Derivates[J].Acta Scientiarum Naturalium Universitatis Pekinensis,1991(6). |
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| Authors: | SONG Yanling Xu Jiaxi HU Jingdan JIN Sheng |
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| Abstract: | Five compounds containing arylamino group were prepared by nucleophilic addition reaction of N-p-fluorobenzoylpropyl-N'-diphenylmethyl piperazine and substituted aromatic amines. Among them, two were made into hydrochloride. The structure of these compounds were proved by 1H-NMR and MS spectra. Meanwhile, we found that the nucleophilic addition reaction is related to the substituting group of aromatic amine. |
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| Keywords: | Piperazine Schiff base Molecular sieve Reductive amination |
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