振雄展势丹对勃起障碍大鼠壮阳作用的研究

探讨专利中药复方振雄展势丹对勃起功能障碍的动物模型的改善作用,并初步探讨其补肾壮阳的作用机理.70只雄性大鼠随机分为7组.除正常组,其余60只雄性大鼠建立勃起功能障碍的去势动物模型,分别灌胃给予振雄展势丹(4,2,1 g/kg),男宝胶囊(200 mg/kg)和丙酸睾酮注射液(2 mg/kg),连续给药21 d.不同剂量振雄展势丹组与模型组相比,勃起潜伏期显著下降.血清睾酮在中、高剂量组的水平明显升高,LH和LSH水平显著降低,且包皮腺,精囊和提肛肌指数明显增加.结果表明,振雄展势丹具有良好的改善勃起功能障碍及补肾壮阳的作用,其作用机理与促进雄性激素分泌,同化激素活性,促进睾丸间质细胞增殖有关.

Aphrodisiac Activity of a Patent Polyherbal Formulation Zhenxiong Exhibition Dan in Castrated Rats

The purpose of this study was to investigate aphrodisiac activity of a patent polyherbal formulation Zhenxiong exhibition dan (ZXD) on ameliorating erectile dysfunction of the rodent model,and preliminarily discuss the mechanism of invigorating the kidney and strengthening yang. 1. Seventy male rats were randomly divided into seven groups. Except for normal group,sixty male rats were castrated to be animal model of sexual dysfunction. The rats in drug-treated groups were intragastrically administrated with different concentration ZXD (4, 2, 1 g/kg), Nanbao capsule (200 mg/kg) and Testosterone propionate injection (TP,2 mg/kg) respectively, for 21 consecutive days. The results show that the erectile latency of drug-treated groups is obvious decreased, the serum levels of T in medial and high dose groups are increased, the serum levels of FSH and LH are significant reduced, and the indexes of preputial gland, seminal vesicle and levatorani muscle are obviously increased.In conclusion, ZXD exerts the aphrodisiac function and ameliorating erectile dysfunction.