Metabolism in Porifera. IX. Studies on the biological conversion of cholesterol into 19-nor-cholestanol by the spongeAxinella polypoides |
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Authors: | L. Minale D. Persico G. Sodano |
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Affiliation: | (1) Laboratorio per la Chimica di Molecole di Interesse Biologico del C.N.R., Via Toiano, 2, Arco Felice, Napoli, Italy;(2) Facoltà di Farmacia, Università, Via L. Rodinò, 22, Napoli, Italy |
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Abstract: | Summary The conversion of cholesterol into 19-nor-5-cholestan-3-ol by the spongeAxinella polypoides involves a partial loss (40%) of the 3-hydrogen atom; moreover administration to the sponge of [4-14C]cholesterol tritiated at C-4 and C-7 showed that the 4- and 7-hydrogen atoms are retained in this conversion. A competitive uptake experiment, [4-14C]cholesterol vs. [7-3H2]5-cholestanol, showed that the sponge utilized exclusively cholesterol for the production of 19-nor-5-cholestan-3-ol.Part of this work has been presented at the Nato Conference on Marine Natural Products (Jersey, Great Britain, October, 1976).-This contribution is part of the Programma finalizzato Oceanografia e Fondi marini-sottoprogetto Risorse biologiche C.N.R. Italy. |
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