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Stimulation of glycoprotein secretion in dispersed rat submandibular gland acini by cystic fibrosis serum
Authors:N. Fleming  Jennifer M. Sturgess
Affiliation:(1) Department of Pathology, The Research Institute, The Hospital for Sick Children, 555 University Avenue, M5G IX8 Toronto, Ontario, Canada
Abstract:Summary Acini were enzymatically dissociated from rat submandibular gland and their mucous glycoproteins radiolabelled with14C-glucosamine. Sera from cystic fibrosis patients stimulated the release of labelled TCA/PTA — insoluble material from the cultured acinar cells to a significantly higher degree than did control sera.This work was supported by the Canadian Cystic Fibrosis Foundation and the Sellers Foundation.
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