Stimulation of glycoprotein secretion in dispersed rat submandibular gland acini by cystic fibrosis serum |
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Authors: | N. Fleming Jennifer M. Sturgess |
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Affiliation: | (1) Department of Pathology, The Research Institute, The Hospital for Sick Children, 555 University Avenue, M5G IX8 Toronto, Ontario, Canada |
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Abstract: | Summary Acini were enzymatically dissociated from rat submandibular gland and their mucous glycoproteins radiolabelled with14C-glucosamine. Sera from cystic fibrosis patients stimulated the release of labelled TCA/PTA — insoluble material from the cultured acinar cells to a significantly higher degree than did control sera.This work was supported by the Canadian Cystic Fibrosis Foundation and the Sellers Foundation. |
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