| 桑葚抗酒精性肝损伤活性部位筛选研究 |
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| 引用本文： | 邓青芳,周欣,陈华国.桑葚抗酒精性肝损伤活性部位筛选研究[J].贵州师范大学学报(自然科学版),2014,32(5):107-110. |
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| 作者姓名： | 邓青芳 周欣 陈华国 |
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| 作者单位： | 贵州省山地环境信息系统与生态环境保护重点实验室,贵州贵阳550001;贵州师范大学天然药物质量控制研究中心,贵州贵阳550001 |
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| 基金项目： | 2012贵阳市科技重大专项计划项目，2013年贵州省中药现代化专项项目 |
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| 摘 要： | 为探讨桑葚鲜果的抗酒精性肝损伤作用,通过采用瓦勒-霍赫法(ValleHoch)体外测定桑葚鲜果醇提物和水提物对乙醇脱氢酶的影响。桑葚鲜果的乙醇、甲醇和水的提取物对乙醇脱氢酶都有不同程度的激活作用,激活率分别为89.34%、60.56%和135.45%,其中桑葚的水提取物效果最佳。
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| 关 键 词： | 桑葚鲜果 乙醇脱氢酶 活性筛选 酒精性肝损伤 |
Study on the protective effects of Fructus Mori against ethanol-induced hepatic injury |
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| DENG Qingfang,ZHOU Xin,CHEN Huaguo.Study on the protective effects of Fructus Mori against ethanol-induced hepatic injury[J].Journal of Guizhou Normal University(Natural Sciences),2014,32(5):107-110. |
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| Authors: | DENG Qingfang ZHOU Xin CHEN Huaguo |
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| Institution: | DENG Qingfang;ZHOU Xin;CHEN Huaguo;Key laboratory for Information System of Mountainous Areas and Protection of Ecological Environment,Guizhou Normal University;The Research Center for Quality Control of Natural Medicine,Guizhou Normal University; |
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| Abstract: | In this study,the alcohol dehydrogenase activity of three different extracts of Fructus Mori fruit,alcohol,methanol and water extracts,were tested by using Valle ＆ Hoch method to illustrate the ethanol-induced acute hepatic injury effects of mulberry fruit extracts.As a result,the water extracts of mulberry fruit show more powerful activationof alcohol dehydrogenase activitycompared to the methanol and alcohol extracts,the activation rate was 89.34％,60.56％ and 135.45％,respectively. |
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| Keywords: | Fructus Mori fruits alcohol dehydrogenase activity screening alcoholic liver injury |
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