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Feasibility Study of Aluminum Hydroxide Sol as Adjuvant to Prepare Stable Vaccine Using Newcastle Disease Virus as a Model |
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| Authors: | SONG Meirong LI Xinsheng GAO Wenming FANG Shaoming CUI Baoan College of Animal Science Veterinary Medicine Henan Agricultural University Zhengzhou Henan China Henan Provincial Key Laboratory of Surface Interface Science Zhengzhou University of Light Industry |
| Institution: | SONG Meirong1,LI Xinsheng1,GAO Wenming1,FANG Shaoming2,CUI Baoan1 1. College of Animal Science and Veterinary Medicine,Henan Agricultural University,Zhengzhou 450002,Henan,China,2. Henan Provincial Key Laboratory of Surface and Interface Science,Zhengzhou University of Light Industry |
| Abstract: | Aluminum hydroxide sol (consisting of aluminum hydroxide nano-particles) prepared by a hydrothermal method was used as nano-aluminum adjuvant adsorbed the inactived Newcastle disease virus (NDV). The zeta potential of aluminum hydroxide colloidal particles,the inactivated NDV and the nano-aluminum adjuvant NDV are +48.16 mV,-13.8 mV and +39.97 mV,respec-tively. The nano-aluminum adjuvant vaccine was transparent and stable without precipitate,whereas the conventional aluminum ad-juvant vaccine was turbid and... |
| Keywords: | nano-aluminum adjuvant aluminum hydroxide sol Newcastle disease vaccine(NDV) hemagglutination inhibition(HI) titer |
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