Research of technique for synthesizing carbonyl diethyl malonate |
| |
Authors: | Houying Gui Liuyu Dong Qiuming Zhou Xinming Hu |
| |
Institution: | GUI Houying,DONG Liuyu,ZHOU Qiuming,HU Xinming School of Sciences,Wuhan University of Technology,Wuhan 430070,Hubei,China |
| |
Abstract: | Diethyl malonate being an initial raw material, processed with chlorination-replacement-desalination-vacuum rectification,
is used to produce carbonyl diethyl malonate. An experiment for optimization determines that the best reaction condition was:
① reaction for 7 h at 10 °C with mole-ratio being 2.4:1 between chloride and raw material (diethyl malonate); ② reaction for
4.5 h at 118 °C with mole-ratio being 1.2:1 between the anhydrous sodium acetate and intermediate I. The final product carbonyl
diethyl malonate recovery ratio reaches up to as high as 79.12% with a purity of 96.4%, which meets the market requirement.
This synthesis technique has the advantages of simple process, moderate reaction conditions, high yield and low cost, being
suitable for industrial scale production. |
| |
Keywords: | diethyl malonate chlorination replacement desalination rectification carbonyl diethyl malonate |
本文献已被 CNKI SpringerLink 等数据库收录! |
|