| 瓜蒌皮提取物对大鼠主动脉Ca^2＋内流的影响 |
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| 引用本文： | 莫尚武,吴玉蓉.瓜蒌皮提取物对大鼠主动脉Ca^2＋内流的影响[J].四川大学学报(自然科学版),1999,36(2):328-331. |
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| 作者姓名： | 莫尚武 吴玉蓉 |
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| 作者单位： | [1]四川大学原子核科学技术研究所 [2]四川大学化学系 |
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| 基金项目： | 国家自然科学基金,核工业科学基金 |
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| 摘 要： | 用醚醇法和水煎醇沉法提取瓜蒌皮的有效成分，并用Ｃａ２＋跨膜测量方法，研究了各提取物对大鼠主动脉ＰＤＣ钙通道Ｃａ２＋内流的影响，以探明瓜蒌皮治疗冠心病的有效组份．结果表明，氯仿和醇溶物能阻滞Ｃａ２＋内流，其中氯仿提取物浓度为３０×１０－３ｇ／ｍＬ时，可使Ｃａ２＋内流量比对照下降３１．５７％，而水溶物的作用则相反；瓜蒌皮中可能有７种具有治疗冠心病的活性组份
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| 关 键 词： | 瓜蒌皮 钙拮抗剂 冠心病 中药 提取物 主动脉 钙 |
INFLUENCE OF THE EXTRACT OF FRUCTUS TRIHOSANTHIS CORTEX ON Ca 2 TRANSMEMBRANE LNFLUX IN RAT AORTA |
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| MO Shan wu,WU Yu rong,YAN Tao,ZHANG Zhu kui.INFLUENCE OF THE EXTRACT OF FRUCTUS TRIHOSANTHIS CORTEX ON Ca 2 TRANSMEMBRANE LNFLUX IN RAT AORTA[J].Journal of Sichuan University (Natural Science Edition),1999,36(2):328-331. |
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| Authors: | MO Shan wu WU Yu rong YAN Tao ZHANG Zhu kui |
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| Abstract: | The fructus trihosanthis cortex was extracted by perobleum etherethanol or/and simmer in water ethanol.The influence of their extracts,14 fractions in all,have been studied on Ca 2 antagonistic effect in rat aorta by using 45 Ca transmembrane influx technique.It was found that 7 fractions are related to activative component on treatment of the coronary heart disease.Among them,The chloroform extract has good Ca 2 blocking effect,which leads Ca 2 influx to decreasing 31.57% by comparision with th control. |
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| Keywords: | fructus trichosanthis cortex Ca 2 antagonist radionuclicle 45 Ca coronary heart disease |
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