Molecularly imprinted polymer for theophylline retention and molecular recognition properties in capillary electrochromatography |
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Authors: | Cai?Ling-shuang Email author" target="_blank">Wu?Cai-yingEmail author Mei?Su-rong Zeng?Zao-rui |
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Institution: | (1) College of Chemistry and Molecular Sciences, Wuhan University, 430072 Wuhan Hubei, China |
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Abstract: | Molecular imprinting of theophylline in poly (methacrylic acid- ethylene dimethacrylate) as CEC stationary phases was synthesized
by an in situ photo-initiated polymerization reaction. The effect of electrolyte pH on xanthine derivatives and the stability
of MIP column performance were investigated. the relative standard deviation (D
RS) of migration time of five consecutive runs on MIP column was in the range of 2.2%–3.1%. The reproducibility of migration
time column to column of M(A) was in the range of 3.8%–4.9%. The highest column efficiency was more than 140 000 plates per
meter. The MIP capillaries had showed better selective for theophylline, which comparing with the reference column. The urine
sample was separated by spiked 5×10−4 mol·L−1 theophylline.
Foundation item: Supported by the National Nature Science Foundation of China (20375028) and the Research Fund for the National High Technology
Development “863” of China (2002AA2Z2004)
Biography: Cai Ling-shuang (1968-), female, Associate professor, Ph. D, research direction: separation science. |
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Keywords: | capillary electrochromatography molecular imprinting polymers theophylline |
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