Neurexins and neuroligins: synapses look out of the nervous system |
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Authors: | Alessia?Bottos Alberto?Rissone Email author" target="_blank">Federico?BussolinoEmail author Email author" target="_blank">Marco?AreseEmail author |
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Institution: | (1) Department of Oncological Sciences, University of Torino, IRCC, Institute for Cancer Research and Treatment at Candiolo, Strada prov 142, km 3, 95, 10060 Candiolo (TO), Italy; |
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Abstract: | The scientific interest in the family of the so-called nervous vascular parallels has been growing steadily for the past 15 years,
either by addition of new members to the group or, lately, by deepening the analysis of established concepts and mediators.
Proteins governing both neurons and vascular cells are known to be involved in events such as cell fate determination and
migration/guidance but not in the last and apparently most complex step of nervous system development, the formation and maturation
of synapses. Hence, the recent addition to this family of the specific synaptic proteins, Neurexin and Neuroligin, is a double
innovation. The two proteins, which were thought to be “simple” adhesive links between the pre- and post-synaptic sides of
chemical synapses, are in fact extremely complex and modulate the most subtle synaptic activities. We will discuss the relevant
data and the intriguing challenge of transferring synaptic activities to vascular functions. |
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Keywords: | |
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