Development of Several New Reactions and Their Application to the Total Synthesis of Biologically Active Natural Products :Synthesis of Linderol A and Determination of Its Absolute Configuration |
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作者姓名: | Shunsaku Ohta |
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作者单位: | Department of Functional Molecular Chemistry, Kyoto Pharmaceutical University, Misasagi, Yamashinoku , Kyoto 607 - 8412, Japan |
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摘 要: | Linderol A (1), a monoterpene-polyketide, was isolated in 1995 from the fresh bark of Lindera umbellata (Lauraceae), and its absolute structure was not determined. It was also reported potent inhibitory activity of 1 on the melanin biosynthesis of the cultured B-16 melanoma cells. See Fig. 1. On the other hand, we reported in 1995 an interesting multi-tandem reaction of coumarin derivatives (2; W = electron withdrawing group) by treatment with CH2 = S(O)Me2 to yield stereoselectively a tricyclic 2-substituted (4) via a cyclopropane intermediate (3) cyclopenta [ b ] benzofuran-3-ol derivative (Scheme 1).
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关 键 词: | 烯酸 自然产物 合成方法 硫磺 立体收敛 |
文章编号: | 0427-7104(2005)05-0783-02 |
收稿时间: | 2005-08-10 |
修稿时间: | 2005-08-10 |
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