The potency of heparin-like activity of glycosaminoglycans released by human endothelial cells in culture |
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Authors: | K Shimada I Kusumoto T Ozawa |
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Institution: | (1) Department of Medicine and Geriatrics, Kochi Medical School, 781-51 Kochi, (Japan) |
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Abstract: | Summary Glycosaminoglycans isolated from culture medium conditioned by human endothelial cells showed heparin-like antithrombin III cofactor activity measured by Xa inhibition. Their activity was relatively weak, 0.1% of the potency of heparin, but was approximately 5-fold more potent than that of glycosaminoglycans derived from vascular smooth muscle cells. |
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Keywords: | Endothelial cells glycosaminoglycan heparin smooth muscle cells |
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