Immunogenicity of fatty acid anilides in rabbits and the pathogenesis of the Spanish toxic oil syndrome |
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| Authors: | A Marquet V Larraga J L Diez C Amela J Rodrigo E Muñoz A Pestaña |
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| Institution: | (1) Unidad de Biomembranas, Instituto de Inumunología y Biología Microbiana, Centro de Investigaciones Biológicas, C.S.I.C., Velázquez, 144, Madrid-6, (Spain);(2) Present address: Instituto de Biología Celular, Centro de Investigaciones Biológicas, C.S.I.C., Arzobispo Morcillo, 4 Madrid-34, Spain;(3) Present address: Instituto  Ramón y Cajal , Centro de Investigaciones Biológicas, C.S. I.C., Arzobispo Morcillo, 4 Madrid-34, Spain;(4) Instituto de Enzimología y Patología Molecular, C.S.I.C, Facultad de Medicina, UAM, Arzobispo Morcillo, 4 Madrid-34, Spain |
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| Abstract: | Summary Fatty acid anilides, the major xenobiotic found in the cooking oils responsible for the Spanish toxic oil syndrome, are immunogenic for rabbits as ascertained by a skin test reaction, the characterization of specific antibodies against anilides and the immunofluorescent detection of  anilide dependent antigens in tissue slices from treated animals.Acknowledgments. This work was supported by a grant from the Fondo de Investigaciones Sanitarias to the C.S.I.C. Programme on Toxic Oil Syndrome. We are indebted to Dr M. Studt and Dr E. Fernández-Alvarez, from the National Center for Organic Chemistry, C.S.I.C., for kindly providing the synthetic fatty acid anilides. We also wish to thank Prof. C. Gitler for helpful discussion. |
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| Keywords: | Spanish toxic oil syndrome oleylanilide linoleylanilide hypersensitivity immunofluorescence immunopathogenesis |
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