Pyrogen fever in rabbits pretreated withp-chlorophenylalanine or 5,6-dihydroxytryptamine |
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| Authors: | M O Carruba H P Bächtold |
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| Institution: | (1) Present address: Department of Pharmacology, School of Medicine, University of Milan, Via Vanvitelli 32, I-20129 Milano, (Italy);(2) Present address: Research Division, F. Hoffmann-La Roche & Co. Ltd., CH-4002 Basel, (Switzerland) |
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| Abstract: | Summary The hyperthermic effect of a bacterial pyrogen has been studied in rabbits pretreated or not withp-chlorophenylalanine or 5,6-dihydroxytryptamine. The results obtained indicate that a selective reduction of cerebral 5-hydroxytryptamine levels by these drugs do not significantly affect pyrogen hypertermia. |
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