The origin of hemopoietic cells in ectopic implants of spleen and marrow

Summary Spleen and marrow tissues were cross-transplanted between CBA and CBA/HT6 mice. The majority of karyotypes in the regenerated implants were of recipient origin indicating that these implants are chimeric structures with the stroma of donor origin providing a framework for the proliferation of the recipient's hemopoietic stem cell.Supported by NIH Grant AM25510-01 and DOE contract 79EV00899. R. Khademi is currently with University of Isfahan, Iran.