ACTH response induced by interleukin-1 is mediated by CRF secretion stimulated by hypothalamic PGE |
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| Authors: | T Watanabe A Morimoto Y Sakata N Murakami |
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| Affiliation: | Department of Physiology, Yamaguchi University School of Medicine, Japan. |
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| Abstract: | We investigated whether hypothalamic prostaglandin E2 (PGE2) and corticotropin releasing factor (CRF) are responsible for the development of the adrenocorticotropic hormone (ACTH) response induced by interleukin-1 alpha (IL-1 alpha). The present results show that ACTH responses induced by intravenous injection of IL-1 alpha were suppressed by systemic pretreatment with indomethacin and that intrahypothalamic injection of PGE2 stimulates the secretion of ACTH. Furthermore, systemic pretreatment with anti-CRF antibody significantly suppressed the ACTH response induced by intrahypothalamic injection of PGE2. These data suggest that the ACTH response induced by IL-1 is mediated by CRF secretion stimulated by hypothalamic PGE2. |
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