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Release of 5-hydroxytryptamine and histamine from neoplastic mast cells by alkaline tissue extracts |
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| Authors: | N. J. Giarman L. T. Potter Margaret Day |
| Affiliation: | (1) Department of Pharmacology, Yale University, School of Medicine, New Haven, Connecticut |
| Abstract: | Zusammenfassung Alkalische Extrakte diverser Rattengewebe setzen 5-Hydroxytryptamin (Serotonin) und Histamin aus Suspensionen neoplastischer Mastzellen der Maus frei. Gehirnund Nierenextrakte zeigen die grösste Aktivität. Zugabe von Glukose in die Nährlösung verhindert das Freiwerden der Amine. Eine vorläufige Charakterisierung des aktiven Materials ist unternommen worden. Aided in part by grant B-940 from National Institute of Neurological Diseases and Blindness, and in part by the James Hudson Brown Memorial Fund of Yale Medical School. This work was done in partial fulfillment of the requirements for the degree of Doctor of Medicine by L. T. P. Squibb post-doctoral fellow in Pharmacology; present address, Department of Pharmacology, Royal College of Surgeons, London. |
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