| 双氢青蒿素醚化法制备蒿甲醚的工艺优化 |
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| 引用本文： | 李雪芳,夏都灵,刘国柱,李颉,李元勋.双氢青蒿素醚化法制备蒿甲醚的工艺优化[J].实验科学与技术,2008,6(2):36-38. |
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| 作者姓名： | 李雪芳 夏都灵 刘国柱 李颉 李元勋 |
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| 作者单位： | 电子科技大学微电子与固体电子学院,成都,610054 |
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| 摘 要： | 采用正交试验法和HPLC分析技术，对蒿甲醚的制备工艺进行优选，以蒿甲醚收率和含量为考察指标，对影响双氢青蒿素醚化的因素进行研究，其醚化的最佳条件为A2B3C4D1，即甲醇与二氯甲烷的体积比为1∶2；双氢青蒿素与三氟乙酸的量之比为10∶1；反应温度为40℃；反应时间为1.5h。该工艺稳定可行。
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| 关 键 词： | 双氢青蒿素 醚化作用 蒿甲醚 正交试验 高效液相色谱 |
| 文章编号： | 1672-4550(2008)02-0036-03 |
| 修稿时间： | 2008年1月15日 |
Optimal Preparation Process of Artemether by Orthogonal Experiments |
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| LI Xue-fang,XIA Du-ling,LIU Guo-zhu,LI Jie,LI Yuan-xun.Optimal Preparation Process of Artemether by Orthogonal Experiments[J].Experiment Science & Technology,2008,6(2):36-38. |
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| Authors: | LI Xue-fang XIA Du-ling LIU Guo-zhu LI Jie LI Yuan-xun |
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| Institution: | ( School of Microeleetranics and Solid - State Electronics, University of Electronic Science and Technology of China, Chengdu 610054, China) |
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| Abstract: | The preparation process is optimized by using an orthogonal design and HPLC. The extraction rate and content of Artemether have been taken for the observed indexes. The best etherificafion condition for dihydroArtemisinine is A2B3C4D1. The ratio of methanol volume over dichloromethane volume is 1 ： 2, the rate of accelerating agent dosage 10： 1, the reaction temperature 40℃ and the reaction time 1.5 hours. When meeting all the conditions, the optimal preparation process was feasible. |
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| Keywords: | dihydroArtemisinine etherification artemether orthogonal experiment high performance liquid chromatograph |
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