| Direct electrochemical detection of PCR product based on charge transfer through DNA |
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| 作者姓名： | ZHAO Hongtao ZHANG Zhijie JU Huangxian |
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| 作者单位： | [1]Key Laboratory of Analytical Chemistry for Life Science, Department ofChemistry, Nanjing University, Nanjing 210093, China |
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| 摘 要： | Human genome project and genetic identification for inherited diseases will definitely have a profound impact on the diagnosis of diseases1], which calls for rapid and accurate assays of DNA. Among different types of sensors, electrochemical DNA biosensors offer a promising alter-native means2,3]. Recent efforts to elucidate the mecha-nism of charge transfer in DNA have demonstrated that the charge transfer is sensitive to the perturbation in base stack4,5]. Long-range charge transfer i…
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| 关 键 词： | 人类 基因组 遗传表达 遗传疾病 DNA 生物传感器 |
| 收稿时间： | 2005-04-30 |
| 修稿时间： | 2005-04-302005-06-13 |
Direct electrochemical detection of PCR product based on charge transfer through DNA |
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| ZHAO Hongtao ZHANG Zhijie JU Huangxian.Direct electrochemical detection of PCR product based on charge transfer through DNA[J].Chinese Science Bulletin,2005,50(15):1666-1668. |
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| Authors: | Zhao Hongtao Zhang Zhijie Ju Huangxian |
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| Institution: | ZHAO Hongtao, ZHANG Zhijie & JU Huangxian Key Laboratory of Analytical Chemistry for Life Science, Department of Chemistry, Nanjing University, Nanjing 210093, China |
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| Abstract: | Human genome project and genetic identification for inherited diseases will definitely have a profound impact on the diagnosis of diseases, which calls for rapid and accurate assays of DNA. Among different types of sensors, electrochemical DNA biosensors offer a promising alternative meanst. Recent efforts to elucidate the mechanism of charge transfer in DNA have demonstrated that the charge transfer is sensitive to the perturbation in base stackt. |
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