Photoreactivation of UV damage in culturedDrosophila cells |
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| Authors: | T M Koval |
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| Institution: | (1) George Washington University School of Medicine and Health Sciences, 20037 Washington, D. C., USA;(2) National Council on Radiation Protection and Measurements, 7910 Woodmont Avenue, Suite 1016, 20814 Bethesda, Maryland, USA |
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| Abstract: | Summary Cell survival and photoreactivation of 254 nm ultraviolet (UV) light damage in a wild typeDrosophila cell line was assayed by colony formation in liquid medium. Fo, Fq, and extrapolation number for the exponential portion of survival curves are 21 J/m2, 3.6 J/m2, and 1.5 for non-photoreactivated cells and 110 J/m2, 11.2 J/m2, and 1.3 for those exposed to photoreactivating light. Maximal photoreactivation occurs at the 100 J/m2 region of the curve. At 10 and 50% survival, 75–80% of the UV damage was photoreactivable. |
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| Keywords: | Cell survival photoreactivation insect cell Drosophila colony formation DNA repair ultraviolet radiation |
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