The EM immunocytochemical demonstration of lysozyme in macrophage giant cells in sarcoidosis

Summary The giant cells (multinucleate macrophages) of human sarcoidosis have been shown by the unlabelled antibody immunoperoxidase technique at electron microscope level to contain lysozyme within cytoplasmic granules.Acknowledgment. We are grateful to M. R. C. Canada for financial support, to Dr S. Erlandsen for instruction in technique, and to Dr L. Black for help in obtaining fresh material.