| 7—羟基—8—甲氧基—4（1H）喹啉酮及其衍生物的合成 |
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| 引用本文： | 龙康侯,孔杰.7—羟基—8—甲氧基—4（1H）喹啉酮及其衍生物的合成[J].中山大学学报(自然科学版),1989,28(1):105-110. |
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| 作者姓名： | 龙康侯 孔杰 |
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| 作者单位： | 中山大学化学系，中山大学化学系 |
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| 摘 要： | 报导了7-羟基-8-甲氧基-4(1H)喹啉酮(Q-A)和它的10种衍生物的合成路线,理化性质及波谱数据;证明了Q-A合成品和由中国软珊瑚Sinularia Polydactyla分离到的天然产物Q-A是一致的。
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| 关 键 词： | 软珊瑚 4-(1H)喹啉酮衍生物 抗心律失常 |
Syntheses of 7-Hydroxy-8-methoxy-4 (1H)-Quinolone and Its Derivatives |
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| Long Kanghou Kong Jie Departmont of Chemistry.Syntheses of 7-Hydroxy-8-methoxy-4 (1H)-Quinolone and Its Derivatives[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,1989,28(1):105-110. |
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| Authors: | Long Kanghou Kong Jie Departmont of Chemistry |
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| Institution: | Long Kanghou Kong Jie Departmont of Chemistry |
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| Abstract: | 7-Hydroxy-8-methoxy-4(1H)-quinolone isolated from the Chinese soft coral Sinularia Polydactyla has been synthesized by a modified Gould-Jacobs' method, The yield is 61%. The synthetic product is identical with the natural one in all respects. Besides, ten other 4-quinolones have also been synthesized. The preliminary bio-assaying tests showed that the presence of the 4-ketonic form of the Q-A derivatives are likely to play an important role in protecting against arrhythmia cordis. |
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| Keywords: | soft coral 4-quinolone derivatives anti-arrhythmia cordis |
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