Hepatitis C viral RNA: challenges and promises |
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| Authors: | Shi S T Lai M M |
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| Institution: | (1) Howard Hughes Medical Institute, and , US;(2) Keck School of Medicine, Department of Molecular Microbiology and Immunology, University of Southern California, 2011 Zonal Avenue, Los Angeles, California 90033 (USA), Fax +1 323 342 9555, e-mail: michlai@hsc.usc.edu, US |
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| Abstract: | Hepatitis C virus (HCV), a positive-sense, single-stranded RNA virus of the Flaviviridae family, is a major cause of chronic
hepatitis, liver cirrhosis, and hepatocellular carcinoma worldwide. Its RNA is difficult to study because biological materials
are scarce and RNA replication is of low efficiency. This review focuses on the structure and functions of HCV RNA along with
their biological and clinical significance. Despite the challenging characteristics of HCV, significant progress has been
made in understanding the properties of HCV RNA and developing viral replication systems toward the improvement of antiviral
therapies.
Received 15 January 2001; received after revision 2 March 2001; accepted 18 April 2001 |
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| Keywords: | , HCV, RNA, structure, heterogeneity, replication, translation, detection, |
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