Highly effective SNP-based association mapping and management of recessive defects in livestock |
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| Authors: | Charlier Carole Coppieters Wouter Rollin Frédéric Desmecht Daniel Agerholm Jorgen S Cambisano Nadine Carta Eloisa Dardano Sabrina Dive Marc Fasquelle Corinne Frennet Jean-Claude Hanset Roger Hubin Xavier Jorgensen Claus Karim Latifa Kent Matthew Harvey Kirsten Pearce Brian R Simon Patricia Tama Nico Nie Haisheng Vandeputte Sébastien Lien Sigbjorn Longeri Maria Fredholm Merete Harvey Robert J Georges Michel |
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| Institution: | Unit of Animal Genomics, GIGA-Research and Department of Animal Sciences, Faculty of Veterinary Medicine, University of Liège (B34), 1 Avenue de l'H?pital, 4000 Liège, Belgium. |
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| Abstract: | The widespread use of elite sires by means of artificial insemination in livestock breeding leads to the frequent emergence of recessive genetic defects, which cause significant economic and animal welfare concerns. Here we show that the availability of genome-wide, high-density SNP panels, combined with the typical structure of livestock populations, markedly accelerates the positional identification of genes and mutations that cause inherited defects. We report the fine-scale mapping of five recessive disorders in cattle and the molecular basis for three of these: congenital muscular dystony (CMD) types 1 and 2 in Belgian Blue cattle and ichthyosis fetalis in Italian Chianina cattle. Identification of these causative mutations has an immediate translation into breeding practice, allowing marker assisted selection against the defects through avoidance of at-risk matings. |
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