Insights into the genetic basis of congenital heart disease |
| |
Authors: | V. Garg |
| |
Affiliation: | (1) Departments of Pediatrics (Division of Cardiology) and Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Rm. NA8.124, Dallas, Texas 75390, USA |
| |
Abstract: | Cardiovascular malformations are the most common type of birth defect and result in significant mortality worldwide. The etiology for the majority of these anomalies remains unknown. Advances in the characterization of the molecular pathways critical for normal cardiac development have led to the identification of numerous genes necessary for this complex morphogenetic process. This work has aided the discovery of an increasing number of single genes being implicated as the cause of human cardiovascular malformations. This review summarizes normal cardiac development and outlines the recent discoveries of the genetic causes of congenital heart disease. Received 4 November 2005; received after revision 14 January 2006; accepted 1 February 2006 |
| |
Keywords: | Congenital heart defects genetics cardiac development |
本文献已被 PubMed SpringerLink 等数据库收录! |