Effects of isoproterenol and dopamine on the myocardial hexose monophosphate shunt.

Long-term exposure of rats to isoproterenol and dopamine resulted in an increase of glucose-6-phosphate dehydrogenase activity and a greater availability of 5-phosphoribosyl-l-pyrophosphate in the myocardium. These results are interpreted to indicate an enhanced flow through the hexose monophosphate shunt.