| 基于冬虫夏草制剂的药物设计研究进展 |
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| 引用本文： | 张栋,史东林,张冠男,谢晓亮,贾东升.基于冬虫夏草制剂的药物设计研究进展[J].科学技术与工程,2014,14(33). |
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| 作者姓名： | 张栋 史东林 张冠男 谢晓亮 贾东升 |
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| 作者单位： | 1. 国家体育总局优秀运动员训练负荷诊断与调控重点实验室,河北省体育科学研究所,石家庄050000
2. 河北省农林科学院经济作物研究所药用植物研究中心,石家庄,050000 |
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| 基金项目： | 河北省科技计划专项资金，河北省体育局体育科技项目 |
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| 摘 要： | 近年来,各种中药制剂的研发取得了较大的进展,冬虫夏草作为名贵中药因其疗效独特而倍受青睐。总结了冬虫夏草各种制剂的设计原理、制备方法、制剂特点和目前存在的一些问题,并对其中活性成分的药理作用、生物利用度等进行了分析;提出未来发展应重视下列方面:1单一活性成分的分离与提纯;2基于药物分子机制对其抗癌活性成分的合理设计;3利用缓控释和靶向控制释放等提高其活性成分的生物利用度;4人工替代品的研制与开发。
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| 关 键 词： | 冬虫夏草制剂 抗癌 药物设计 研究进展 |
| 收稿时间： | 2014/6/23 0:00:00 |
| 修稿时间： | 2014/7/18 0:00:00 |
Research progress of drug design based on Cordyceps pharmaceutics |
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| ZHANG Dong,SHI Dong-lin,ZHANG Guan-nan,XIE Xiao-liang and JIA Dong-sheng.Research progress of drug design based on Cordyceps pharmaceutics[J].Science Technology and Engineering,2014,14(33). |
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| Authors: | ZHANG Dong SHI Dong-lin ZHANG Guan-nan XIE Xiao-liang and JIA Dong-sheng |
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| Institution: | Key Laboratory of training load diagnostics and regulating of elite athletes of General Administration of Sport of China,Sports Science Institute of Hebei Province,Hebei,Shijiazhuang,Key Laboratory of training load diagnostics and regulating of elite athletes of General Administration of Sport of China,Sports Science Institute of Hebei Province,Hebei,Shijiazhuang,Institute of cash crops of Hebei Academy of Agriculture and Forestry Sciences,Centre of medicinal plant research,Hebei,Shijiazhuang,Institute of cash crops of Hebei Academy of Agriculture and Forestry Sciences,Centre of medicinal plant research,Hebei,Shijiazhuang |
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| Abstract: | In recent years, research and development of various herbal preparations made great progress, Cordyceps,acclaimed for its unique effect as valuable medicine. This paper summarizes the design principles, preparation method, preparation characteristics and existing problems of Cordyceps, analyzed pharmacological effects and bioavailability of the active ingredient. It was proposed future development should pay attention to the following aspects: (l) Isolation and purification of a single active ingredient (2) based on its anticancer mechanism of drug molecules to the rational design of active ingredient (3) the use of slow-release and controlled-release and other targeted controlled release improve the bioavailability of the active ingredient (4) artificial substitute product research and development. |
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| Keywords: | Cordyceps pharmaceutics anticancer drug design Research progress |
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