Inhibition by carbaryl of DNA,RNA and protein synthesis in cultured rat lung cells |
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| Authors: | J. M. Lockard B. P. Schuette P. S. Sabharwal |
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| Affiliation: | (1) Thomas Hunt Morgan School of Biological Sciences, University of Kentucky, 40506 Lexington, Kentucky, USA |
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| Abstract: | Summary The carbamate pesticide carbaryl rapidly inhibited DNA, RNA and protein synthesis in L-2 cells from rat lung. the inhibiton was partly reversible and was not accompanied by inhibiton of transport of tritiated precursors into intracellular pools or destruction of the integrity of the cell membrane.We thank W. H. J. Douglas for his gift of L-2 cells.This work was supported by contract 22140 of the Kentucky Tobacco Research Board. |
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