Evolution and molecular epidemiology of foot-and-mouth disease virus in China |
| |
Authors: | XingWen Bai PingHua Li HuiFang Bao ZaiXin Liu Dong Li ZengJun Lu YiMei Cao YouJun Shang JunJun Shao HuiYun Chang JianXun Luo XiangTao Liu |
| |
Affiliation: | State Key Laboratory of Veterinary Etiological Biology,National Foot-and-Mouth Disease Reference Laboratory,Engineering Research Center of Biological Detection of Gansu Province,Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730046,China |
| |
Abstract: | Foot-and-mouth disease (FMD), caused by foot-and-mouth disease virus (FMDV), is considered one of the most important viral diseases of cloven-hoofed animals, causing severe economic losses in affected regions of the world. Three serotypes (A, O, and Asia 1) of FMDV have been identified in China since 1958. In addition, the occurrence of novel subtypes within these serotypes has made the epidemiology of FMDV more complicated over the last few years. In this review, we summarize the history and the current epidemiological situation in China, genetic diversity (e.g., quasispecies dynamics, antigenic heterogeneity, and functional constraints), intertypic recombination, and the evidence for positive selection of different FMDV serotypes. We also assess these genetic data to understand the origin, evolution, and transmission of FMDV, the findings of which may be useful in developing control measures for future epidemics. |
| |
Keywords: | foot-and-mouth disease virus phylogenetic analysis recombination positive sdection |
本文献已被 CNKI 维普 SpringerLink 等数据库收录! |
|