血管紧张素转换酶基因多态性与糖尿病的相关性研究

为了研究血管紧张素转换酶(ACE)基因的插入(I)/缺失(D)多态性是否与糖尿病(DM)的易感性相关,对108例糖尿病患者和196例正常人进行了ACE基因多态性分析.发现DM患者基因型DD基因型频率为22%,χ2=4.7,P>0.05(其中,Ⅰ型糖尿病患者相应频率为21%,χ2=4.9,P>0.05;Ⅱ型糖尿病患者为23%,χ2=2.1,P>0.05),而对照组DD基因型频率为16%;DM患者D等位基因频率为38%,χ2=0.0048,P>0.05(其中,Ⅰ型糖尿病患者相应频率为34%,χ2=0.62,P>0.05;Ⅱ型糖尿病患者为41%,χ2=0.25,P>0.05),而对照组相应频率分别为38%.糖尿病患者与对照组之间ACE基因I/D多态性频率存在差异,但不显著.这一结果表明ACE基因的多态性与糖尿病的易感性可能无关.

Relationship between angiotensin converting enzyme gene polymorphism and diabetes mellitus patient

To investigate whether angiotensin I converting enzyme (ACE)gene insertion/deletion(I/D)polymorphism is associated with the susceptibility to diabetes mellitus(DM),analyzed the ACE gene polymorphism in 108 patients with DM(43 patients with type 1 diabetes,65 patients with type 2 diabetes)and 196 control subjects.The genotype frequencies for DD were 22?% in the DM group (and it was 21?% in patients with type 1 diabetes;and (23?%) in patients with type 2 diabetes,respectly)and 16?% in the control subjects,respectly.This study showed that the DD frequency is not significantly higher in the patients than in the control group (P>0.05),and so is the D allele ,suggesting that the DD genotype maybe not associated with the susceptibility to DM in our study group and that there maybe no correlation between ACE gene polymorphism and susceptibility to DM.