| 邻苯二甲酰基化κ-卡拉胶的合成及其生物活性 |
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| 引用本文： | 郭锡坤,余成艳.邻苯二甲酰基化κ-卡拉胶的合成及其生物活性[J].汕头大学学报(自然科学版),2007,22(1):37-41,53. |
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| 作者姓名： | 郭锡坤 余成艳 |
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| 作者单位： | 汕头大学理学院生物系,广东,汕头,515063 |
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| 摘 要： | 采用硫酸水解法将κ-卡拉胶降解为低分子量卡拉胶,并制成四丁基铵盐,在适宜的反应体系中与邻苯二甲酸酐反应,得到低分子量κ-卡拉胶O-邻苯二甲酰基化衍生物。借助FT-IR对其结构进行分析,并测试酰化衍生物的凝集活性及抗氧化活性.结果表明,降解后κ-卡拉胶的结构单元没有被破坏,邻苯二甲酰基被成功地引入到κ-卡拉胶的分子链上,酰化衍生物表现出显著的血细胞凝集活性.
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| 关 键 词： | 低分子量κ-卡拉胶(LMW-KC) 酰化 邻苯二甲酸酐 凝集活性 血细胞 生物活性 |
| 文章编号： | 1001-4217（2007）01-0037-05 |
| 收稿时间： | 2006-07-12 |
| 修稿时间： | 2006-07-12 |
Preparation and the Biological Activities of Phthaloyl κ-Carrageenan |
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| GUO Xi-kun,YU Cheng-yan.Preparation and the Biological Activities of Phthaloyl κ-Carrageenan[J].Journal of Shantou University(Natural Science Edition),2007,22(1):37-41,53. |
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| Authors: | GUO Xi-kun YU Cheng-yan |
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| Institution: | College of Science, Shantou University, Shantou 515063, Guangdong, China |
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| Abstract: | Low-molecular-weight(LMW) κ-Carrageenan is achieved through mild sulfuric acid hydrolysis of κ-Carrageenan,and then is turned into tetrabutyl-ammonium salt(TBA).The salt is then acylated with phthalic anhydride in the suitable system,resulting in O-phthalyl derivatives of LMW-KC.Investigation of FT-IRspectrum shows that the disaccharide repeating unit of κ-Carrageenan is not destroyed after the degradation and the phthaloylated LMW κ-Carrageenan is successfully formed when LMW κ-Carrageenan reacts with phthalic anhydride.The biological activity shows that the phthaloylated LMW κ-Carrageenan has extraordinarily agglutinative function. |
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| Keywords: | low-molecular-weight κ-Carrageenan(LMW-KC) acylation phthalic anhydrade agglutinative activity erythrocyte biological activity |
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