Solacasine,a new steroidal alkaloid fromSolanum pseudocapsicum possessing antimicrobial activity |
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| Authors: | L A Mitscher J V Juvarkar J L Beal |
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| Institution: | (1) Department of Medicinal Chemistry, The University of Kansas, 66045 Lawrence, Kansas, USA;(2) Present address: Division of Pharmacognosy, The Ohio State University, 43210 Columbus, Ohio, USA |
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| Abstract: | Summary Systematic fractionation of alcohol extracts ofSolanum pseudocapsicum. showed that solacasine is the main antibacterial constituent. Based on physiochemical studies, a structure is proposed.The authors are grateful to Dr.R. Foltz, Battelle's Columbus Laboratories, and Mr.E. Fairchild of our laboratories for the mass spectral data, to Mr.Ruey-Ping Leu for the microbiological data, and to the NIH for grant No. AI-09846 in partial support of this work. |
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