An uptake of fluorescein isothiocyanate labeled neocarzinostatin into the cancer and normal cells |
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Authors: | S Sakamoto H Maeda J Ogata |
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Institution: | (1) Departments of Urology and Microbiology, Kumamoto University Medical School, Honjo 1-1-1, 860 Kumamoto, Japan |
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Abstract: | Summary An uptake of fluorescein isothiocyanate labeled neocarzinostatin into normal and cancerous epithelial cells from bladder was investigated. Results showed that neocarzinostatin traversed the cell membrane into cytosol and nuclei, and it appeared to have a preferential cytotoxicity for the cancer cell.This investigation was supported in part by a Grant-in-Aid for cancer research from the Ministry of Education, Science and Culture (H.M.) and from the Ministry of Welfare (O.J.). |
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