Growth hormone alters lymphocyte sub-populations and antibody production in dwarf rats in vivo |
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Authors: | A Schurmann G S G Spencer C J Berry |
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Institution: | (1) Ruakura Agricultural Centre, Private Bag 3123, Hamilton, (New Zealand) |
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Abstract: | Female dwarf rats at different ages were treated with recombinant porcine GH or with a potent sheep anti-rat GH serum. Body weight and spleen weight increased with GH and decreased with anti-GH treatment (p<0.001). Neither GH nor anti-GH treatment resulted in a change in circulating WBCs, but GH decreased, while anti-GH increased, RBC counts (p<0.001). Similarly, GH treatment tended to decrease the ratio of CD4+:CD8+ T-cells while anti-GH increased (p<0.05) the ratio. Anti-GH treatment also enhanced the animals' ability to produce specific IgG in response to KLH injection. These results indicate that GH may have a physiological role in suppressing humoral immune function but may enhance cell-mediated immunity. |
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Keywords: | Growth hormone thymus spleen lymphocytes antibodies immune function |
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