The history of cyclosporin A (Sandimmune®) revisited: Another point of view |
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| Authors: | H F Stähelin |
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| Institution: | (1) Hardstrasse 80, CH-4052 Basel, (Switzerland) |
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| Abstract: | The immunosuppressant cyclosporin A (Sandimmune®) has become the first line treatment for preventing rejection of transplanted organs and for certain, autoimmune diseases. The discovery of that drug and its preclinical development are described, and it is shown that most earlier accounts of the history of this compound are, in important respects, incorrect and misleading. |
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| Keywords: | Cyclosporin A Sandimmune® ovalicin cytochalasin fungus metabolites history discovery |
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