The role of sialic acid in determining the survival of circulating interferon |
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| Authors: | V Bocci A Pacini G P Pessina V Bargigli M Russi |
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| Institution: | (1) Istituto di Fisiologia Generale and Istituto di Microbiologia dell' Università di Siena, via Laterina 8, I-53100 Siena, (Italy) |
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| Abstract: | Summary Rabbit interferon has been extensively desialylated and its metabolic behaviour has been evaluated in the rabbit. The half-life of asialointerferon is significantly shorter than the native interferon and its urinary excretion becomes negligible. Moreover the rapid uptake of asialointerferon by the isolated and perfused rabbit liver, suggests a hitherto unsuspected catabolic pathway for this glycoprotein.This work was supported by a grant from the Consiglio Nazionale delle Ricerche, Roma (subproject on antiviral therapy), contract No. 76.00646.84). |
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