Medium- and short-chain dehydrogenase/reductase gene and protein families |
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| Authors: | H Eklund S Ramaswamy |
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| Institution: | 1. Department of Molecular Biology, Swedish University of Agricultural Sciences, Box 590, BMC S 75124, Uppsala, Sweden
2. Department Biochemistry, University of Iowa, Iowa City, 52242, USA
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| Abstract: | In this report we describe the main features of the initially determined alcohol dehydrogenase, that of horse liver, relate
this to the human enzyme structures and review recent structural studies on mutants and new complexes of the enzymes. We further
review the structure of a bacterial alcohol dehydrogenase to arrive at a coherent picture of medium-chain dehydrogenase/reductase
alcohol dehydrogenases in general. |
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| Keywords: | |
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