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| Matrix metalloproteinases （MMPs） and trophoblast invasion | |
| 作者姓名： | LIJing ZHAOTianfu DUANEnkui |
| 作者单位： | [1]StateKeyLaboratoryofReproductiveBiology,InstituteofZoology,ChineseAcademyofSciences,Beijing100080,China／／GraduateSchooloftheChineseAcademyofSciences,Beijing100039,China [2]DepartmentofBiology,BaodingTeacher＇sCollege,Baoding071000,China [3]StateKeyLaboratoryofReproductiveBiology,InstituteofZoology,ChineseAcademyofSciences,Beijing100080,China |
| 摘 要： | MMPs and their natural tissue inhibitors TIMPs are crucial in coordinated breakdown and remodeling of the extracellular matrix (ECM) in physiological and pathological situations. Placentation is a key event of pregnancy in which MMPs/TIMPs system plays important roles in regulating the extravillus cytotrophoblast (EVTs) invasion. This paper focuses on expression patterns and regulatory mechanisms of MMPs/TIMPs family members during the process of placentation. Their implications in curing pregnancy-related diseases are also discussed. |
| 关 键 词： | MMPs 细胞外矩阵 组织抑制剂 胚胎入侵 胎盘 |
| 收稿时间： | 2004-12-06 |
Matrix metalloproteinases (MMPs) and trophoblast invasion |
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| LIJing ZHAOTianfu DUANEnkui.Matrix metalloproteinases (MMPs) and trophoblast invasion[J].Chinese Science Bulletin,2005,50(12):1169-1173. | |
| Authors: | Jing Li Tianfu Zhao Enkui Duan |
| Institution: | 1. State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100080, Beijing, China 2. Graduate School of the Chinese Academy of Sciences, 100039, Beijing, China 3. Department of Biology, Baoding Teacher’s College, 071000, Baoding, China |
| Abstract: | MMPs and their natural tissue inhibitors TIMPs are crucial in coordinated breakdown and remodel- ing of the extracellular matrix (ECM) in physiological and pathological situations. Placentation is a key event of pregnancy in which MMPs/TIMPs system plays important roles in regulating the extravillus cytotrophoblast (EVTs) invasion. This paper focuses on expression patterns and regulatory mechanisms of MMPs/TIMPs family members during the process of placentation. Their implications in curing pregnancy-related diseases are also discussed. |
| Keywords: | MMPs TIMPs placenta trophoblast invasion extracel- lular matrix (ECM) |
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