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Psoriasis is associated with increased beta-defensin genomic copy number |
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| Authors: | Hollox Edward J Huffmeier Ulrike Zeeuwen Patrick L J M Palla Raquel Lascorz Jesús Rodijk-Olthuis Diana van de Kerkhof Peter C M Traupe Heiko de Jongh Gys den Heijer Martin Reis André Armour John A L Schalkwijk Joost |
| Affiliation: | Department of Genetics, University of Leicester, Leicester LE1 7RH, UK. |
| Abstract: | Psoriasis is a common inflammatory skin disease with a strong genetic component. We analyzed the genomic copy number polymorphism of the beta-defensin region on human chromosome 8 in 179 Dutch individuals with psoriasis and 272 controls and in 319 German individuals with psoriasis and 305 controls. Comparisons in both cohorts showed a significant association between higher genomic copy number for beta-defensin genes and risk of psoriasis. |
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