Chronic stress induced proliferation and activation of mast cells of gastric antrum in rats |
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Authors: | Zhenhua Chen Gaohua Wang Heshen Luo Jihong Chen Yonglan Huang Xiaoping Wang Senlin Lei |
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Affiliation: | [1]Department of Psychiatry, Renmin Hospital of WuhanUniversity, Wuhan 430060, Hubei, China [2]Department of Gastroantrology, Renmin Hospital of Wuhan university, Wuhan 430060, Hubei, China [3]Research Center of Medicine and Structure Biology, Schoolof Medicine, Wuhan University, Wuhan 430071, Hubei, China |
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Abstract: | To explore chronic heterotypic stressors induced proliferation and activation of mast cells in gastric antrum mucosa by ultrastructure alterations of mast cells, chronic unpredictable heterotypic stressors were used as a study model. The mean immunofluorescence magnitude of mast cell protease 1 (MCP-1) taken from chronic stress rats were 37.4±7.7, significantly higher (p<0.05) than the value of normal control group (24.8±5.6). Chronic unpredictable haterotypic stressors appeared also to induce ultrastructure alterations of mast cells. It indicated that mast cells were proliferated and activated, while mast cell granules were hyperplasiaed. Most granules had obvious intragranular changes with loss of electron-dense material. The morphologic evidence showed that macrophages and leukocytes infiltrated in chronic stress rats. Some granules of leukocytes adhered to the surface of mast cell, and formed a bridge. Macrophages phagocytized the mast cell granules. Biography: CHEN Zhenhua(1967–), male, M.D. candidate, Associate professor, research direction:Psychosomatic disease and psychopharmacology. |
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Keywords: | mast cells gastric antrum morphology chronic stress |
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