| 海南青梅中白藜芦醇类化合物及其抗肿瘤活性研究 |
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| 引用本文： | 陈文豪,李玖慧,惠阳,宋小平,陈光英,韩长日,韩姣姣. 海南青梅中白藜芦醇类化合物及其抗肿瘤活性研究[J]. 海南师范大学学报(自然科学版), 2014, 0(4): 401-403 |
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| 作者姓名： | 陈文豪 李玖慧 惠阳 宋小平 陈光英 韩长日 韩姣姣 |
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| 作者单位： | 1. 海南师范大学 化学与化工学院，海南 海口 571158; 海南师范大学 热带药用植物化学教育部重点实验室，海南 海口 571158
2. 海南师范大学 化学与化工学院,海南 海口,571158 |
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| 基金项目： | 国家自然科学基金项目(21202030)；海南省自然科学基金项目(213022)；大学生创新创业训练计划(2013116580)；海南师范大学博士科研启动基金 |
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| 摘 要： | 在活性追踪指导下,综合运用硅胶、Sephadex LH-20柱色谱等分离技术,从海南青梅茎乙醇提取物的乙酸乙酯萃取部位分离得到4个白藜芦醇类化合物.根据ESIMS、NMR波谱数据结合理化性质,并通过与文献对照,鉴定化合物的结构分别为：diptoindonesin G（1）,（＋）-ε-viniferin（2）,hopeahainol（3）和hopeahainol C（4）,化合物1为首次从该属植物中分离得到.抗肿瘤活性表明,化合物1对小鼠黑色素瘤细胞（B16F10）和人肺腺癌细胞（A549）均具有微弱的增殖抑制活性,IC50值分别为36.1,20.4μM.
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| 关 键 词： | 海南青梅 白藜芦醇类化合物 结构鉴定 抗肿瘤活性 |
Resveratrol Compounds and Their Antitumor Activities From the Stems of Vatica mangachpoi |
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| CHEN Wenhao,LI Jiuhui,HUI Yang,SONG Xiaoping,CHEN Guangying,HAN Changri,HAN Jiaojiao. Resveratrol Compounds and Their Antitumor Activities From the Stems of Vatica mangachpoi[J]. Journal of Hainan Normal University:Natural Science, 2014, 0(4): 401-403 |
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| Authors: | CHEN Wenhao LI Jiuhui HUI Yang SONG Xiaoping CHEN Guangying HAN Changri HAN Jiaojiao |
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| Affiliation: | CHEN Wenhao, LI Jiuhui, HUI Yang, SONG Xiaoping, CHEN Guangying, HAN Changri, HAN Jiaojiao ( 1. College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China; 2. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571199, China; ) |
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| Abstract: | Under the guidance of bioassay, column chromatography on silica gel and Sephadex LH-20 were used to isolate and purify the compounds from the EtOAc extract of the stems of Vatica mangachpoi. Four resveratrol compounds were obtained and their structures were established as diptoindonesin G （1）,（＋）-ε-viniferin （2）, hopeahainol （3）, and hopeahainol C （4） on the basis of ESIMS, NMR data analysis and by comparison with spectroscopic data reported in the literature. Compound 1 was isolated from Vatica genus for the first time, which also showed weak inhibitory activities against mouse melanoma cells （B16F10） and human lung adenocarcinoma cells （A549）, with ICso values of 36.1, and 20.4 μM, respectively. |
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| Keywords: | vatica mangachpoi resveratrol compounds structural identification antitumor activities |
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