Biotransformation,byEnterobacter agglomerans,of pyrimidine acyclonucleosides to acyclonucleotides |
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| Authors: | M Rutkowski E Korczak |
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| Institution: | (1) Department of General Chemistry, Institute of Basic Sciences, Military Medical Academy, Plac Hallera 1/3, 90-647 Lodz, (Poland);(2) Department of Medical Microbiology, Institute of Basic Sciences, Military Medical Academy, Plac Hallera 1/3, 90-647 Lodz, (Poland) |
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| Abstract: | The ability ofEnterobacter agglomerans to transform naturally occurring nucleosides into nucleotides has been utilized to transform newly synthesized pyrimidine acyclonucleosides into the corresponding acyclonucleotides. Unselected bacteria were used as the source of nucleoside phosphotransferase, the phosphate group donor being 4-nitrophenyl phosphate in the presence of Zn2+ ions. Optimal reaction conditions are outlined. |
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| Keywords: | Nucleoside phosphotransferase enzymic synthesis of acyclonucleoside phosphates |
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