The localization of type 2 diabetes susceptibility gene loci in northern Chinese Han families |
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| Authors: | Jinying Zhao Heng Wang Momiao Xiong Wei Huang Jin Zuo Zhu Chen Boqin Qiang Qi Sun Yuxiu Li Qiuying Liu Weinan Du Jialun Chen Wei Ding Wentao Yuan Yang Zhao Hongyan Xu Li Jin Fude Fang |
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| Institution: | (1) Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Chinese National Human Genome Center at Beijing, 100005 Beijing, China;(2) Department of Endocrinology, Peking Union Medical College Hospital, 100730 Beijing, China;(3) Ruijin Hospital, Shanghai Second Medical University, Shanghai Institute of Hematology, Chinese National Human Genome Center at Shanghai, 201203 Shanghai, China;(4) Shanghai Institute of Endocrinology, 200025 Shanghai, China;(5) Ruijin Hospital, Shanghai Second Medical University, 200025 Shanghai, China;(6) Morgan-Tan International Central for Biological Sciences, Fudan University, 200433 Shanghai, China |
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| Abstract: | We conducted a genome-wide scan, in which 358 well distributed fluorescent dye-labeled microsatellite marker sets were applied
in 32 Chinese Han type 2 diabetes families from Northern China to search for the susceptibility gene loci. The data collected
from screening all the chromosomes of genome were genotyped by using genescan and genotyping software, then, parametric and
non-parametric multipoint test, and affected sib-pair analysis as well, were used to analyze the data. We identified some
susceptibility gene loci residing in chromosomes 1, 12, 18, 20, respectively, or precisely, located around D1S214, D1S207,
D1S218, D1S235, D12S336, D18S61 and D20S118. The comparison of this result with those from other regions and races reflected
the complexity and heterogeneity of type 2 diabetes. |
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| Keywords: | Northern Han Chinese type 2 diabetes susceptibility gene locus |
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