| 抗弯刚度对盐溶液中DNA构型的影响 |
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| 引用本文： | 王永昭,张琪昌,王炜.抗弯刚度对盐溶液中DNA构型的影响[J].科学技术与工程,2015,15(8). |
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| 作者姓名： | 王永昭 张琪昌 王炜 |
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| 作者单位： | 天津大学机械工程学院,天津市非线性动力学与混沌控制重点实验室,天津300372 |
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| 基金项目： | 国家自然科学基金项目（面上项目，重点项目，重大项目）;国家教育部博士点基金 |
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| 摘 要： | 作为DNA连续体模型,界面压力下的弹性杆模型被作为研究盐溶液中DNA平衡构型.研究界面牵引力,盐离子浓度的变化和抗弯刚度变化对构型影响.结果显示DNA凝缩主要受界面牵引力和抗弯刚度影响,随着抗弯刚度的变化,DNA将经历从初始构型到凝缩构型的一系列变化,螺旋型构型的出现与实验中观察现象一致.
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| 关 键 词： | 界面牵引力 凝缩构型 离子浓度 各向异性 |
| 收稿时间： | 2014/10/29 0:00:00 |
| 修稿时间： | 2014/11/19 0:00:00 |
The Effect of Bending Elasticity on the Equilibrium Configuration of DNA in solution |
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| WANG Yong-zhao
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ZHANG Qi-chang
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WANG Wei.The Effect of Bending Elasticity on the Equilibrium Configuration of DNA in solution[J].Science Technology and Engineering,2015,15(8). |
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| Authors: | WANG Yong-zhao ZHANG Qi-chang WANG Wei |
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| Institution: | Tianjin Key Laboratory of Nonlinear Dynamics and Chaos Control,Tianjin University |
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| Abstract: | As a continuum model of DNA, a thin elastic rod subjected to interfacial interactions is used to investigate the equilibrium configuration of DNA in salt solution. In this paper the anisotropic bending elasticity models are established to characterize the change of the interfacial traction and the elastic modulus. The influences of the ionic concentration and anisotropic bending elasticity on the equilibrium configuration of DNA are discussed. The results show that the condensation of DNA is mainly determined by the interfacial tractions and the bending elasticity. With the change of the elasticity, the DNA segments will undergo a series of alteration from the original configuration to the condensed configuration, and the spiral-shape appearing in the condensed configuration of DNA shows a fairly well agreement with experimental observation. |
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| Keywords: | Interfacial traction Condensation Ionic concentration Anisotropic |
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