| 甲磺酸多沙唑嗪热氧降解历程与动力学研究 |
| |
| 引用本文： | 魏月英,林木良,李晓燕.甲磺酸多沙唑嗪热氧降解历程与动力学研究[J].中山大学学报(自然科学版),2000,39(2):128-130. |
| |
| 作者姓名： | 魏月英 林木良 李晓燕 |
| |
| 作者单位： | ：魏月英(中山大学测试中心，广州 510275);林木良(中山大学测试中心，广州 510275) |
| |
| 摘 要： | 用热重法、微分热重法、和差热分析法研究药物甲磺酸多沙唑嗪在空气流中的热氧降解过程和热氧降解动力学，发现该药物的热氧降解过程由４个紧连步骤组成。用Ｃｏａｔｓ－Ｒｅｄｆｅｒｎ方程进行动力学处理，确定该药物热氧降解的表观反应级数分别为１．１、１．５、１．５、１．２和反应活化能为３５３．７，２３９．５，２２９．９和１６７．２ｋＪ／ｍｏｌ。
|
| 关 键 词： | 药物热氧降解 动力学 甲磺酸多沙唑嗪 |
| 文章编号： | 0529-6579(2000)02-0128-03 |
| 修稿时间： | 1999-09-01 |
The Thermal Oxidation
Degradation Process and
Kinetics of Doxazolazine Methylsulfonate |
| |
| WEI Yue-ying LIN Mu-liang,LI Xiao-yan.The Thermal Oxidation
Degradation Process and
Kinetics of Doxazolazine Methylsulfonate[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2000,39(2):128-130. |
| |
| Authors: | WEI Yue-ying LIN Mu-liang LI Xiao-yan |
| |
| Abstract: | DTA and TG/DTG techniques were used to study the thermal oxidation degradation process and kinetics of doxazolazine methylsulfonate in air. It was found that the thermal oxidation degradation process of doxazolazine methylsulfonate is in four steps. kinetic treatment with Coats-Redfem equation showed that the apparent degradation reaction orders are 1. 1, 1.5, 1.5, 1.2 and the activation energies are 363 .7, 239.5, 229.9 and 167.2 kJ/mol, respectively. |
| |
| Keywords: | doxazolazine methylsulfonate thermal oxidation degradation thermal oxidation degradation kinetics |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
