Mechanisms of coronary vasoconstriction induced by Na arachidonate in experimentally diabetic dogs |
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| Authors: | L Sterin-Borda E Borda E J del Castillo M F Gimeno A L Gimeno |
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| Institution: | (1) Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Serrano 665/69, 1414 Buenos Aires, (Argentina) |
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| Abstract: | Summary Na arachidonate (NaA) enhanced the resting basal tone of isolated coronary arteries from diabetic dogs and depressed it in coronary arteries from normal controls. Inhibitors of thromboxane A2 biosynthesis and of lipoxygenases abolished the vasoconstrictor effect of NaA on diabetic arteries, whereas inhibitors of cyclooxygenase activity and PGI2 biosynthesis blocked the vasodilating action of NaA on normal arteries.This work has been supported by grant 6638 from CONICET (Argentina). |
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