Expanded flux variability analysis on metabolic network of Escherichia coli |
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| Authors: | CHEN Tong XIE ZhengWei & OUYANG Qi Center for Theoretical Biology School of Physics Peking University Beijing China |
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| Institution: | CHEN Tong1,XIE ZhengWei1 & OUYANG Qi1,2 1 Center for Theoretical Biology , School of Physics,Peking University,Beijing 100871,China,2 Department of Physics,Hong Kong Baptist University,Kowloon Tong,Hong Kong |
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| Abstract: | Flux balance analysis, based on the mass conservation law in a cellular organism, has been extensively employed to study the interplay between structures and functions of cellular metabolic networks. Consequently, the phenotypes of the metabolism can be well elucidated. In this paper, we introduce the Expanded Flux Variability Analysis (EFVA) to characterize the intrinsic nature of metabolic reactions, such as flexibility, modularity and essentiality, by exploring the trend of the range, the maximum and the... |
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| Keywords: | metabolic network flux balance analysis modularity essentiality |
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