乌司他丁联合应用血必净治疗脓毒症的疗效评价

目的评价乌司他丁联合血必净注射液治疗脓毒症的有效性和安全性,以及比单用血必净注射液治疗脓毒症的优越性。方法将50例出现脓毒血症的患者随机分为对照组和试验组,每组25例,对照组患者给予抗生素、血必净注射液50 mL,静脉滴注,1次/12 h,对症及常规营养支持治疗,如病情需要可予脏器代替治疗,包括使用呼吸机和/或血液透析H试验组患者在对照组治疗的基础上加用乌司他丁60万U,静脉滴注,1次/12 h,连用10 d。结果对照组患者的病死率为44%,试验组为12%,两组患者病死率间差别有显著性意义（P〈0.05）。结论加用乌司他丁可降低脓毒血症的病死率,在脓毒症的治疗中应有良好前景。

Effect of ulinastatin combine Xuebijing in treatmeut of sepsis

Objective： To evaluate the effectiveness and safety of the ulinastatin Combine Xuebijingin in the treatment of sepsis,and the superiority than the single-use Xuebijing injection.Methods：Thirty sepsis patients were divided into the test group and the comparison group,each of 15 patients,and the comparison group was treated by antibiotics 、xuebijing 50 ml,ivd,q12h;symptomatic treatment and conventional nutritional support,and if the patients need,they can be given organ replacement therapy,including the use of respiratory machine and / or hemodialysis;the test group,on the basis of the comparison group,was plus treated ulinastatin 600,000 U,ivd,q12h,10 days.Resluts：The mortality of the test group was 33.3%,the comparison group was 20%,it had a significant difference between the two groups,P〈0.05.Conclusion：The ulinastatin be plus used can reduce the mortality of sepsis,it would have a good prospects in the treatment of sepsis.